John H. Holmes, PhD

John H. Holmes, PhD
Senior Fellow

Professor of Medical Informatics in Epidemiology, Perelman School of Medicine/Department of Biostatistics, Epidemiology, and Informatics

Public Health Interests

Environmental Health, Social Determinants of Health



Current Public-Health Related Activities

My own research interests are focused on several areas in medical informatics, specifically evolutionary computation and machine learning approaches to knowledge discovery (data and text mining) in biomedical and other databases and interoperable information systems infrastructures for epidemiologic surveillance. I was the principal investigator on an NLM-funded project to develop an ontology-based text mining on tool to analyze social media for evidence of self-reported natural supplement-associated adverse events and interactions. I currently lead the evaluation of two PCORnet obesity projects, and serve as the Principal Investigator of the Penn Center of Excellence in Health Disparities. I am the evaluator for the PCORNet Obesity Initiative studies, responsible for developing and implementing the evaluation plan and metrics for the initiative. I am currently a co-investigator on a project funded by the Cardiovascular Medical Research and Education Fund (CMREF), leading the effort to harmonize 30 clinical trials in pulmonary arterial hypertension.

Select Publications:

Maffei RM, Dunn K, Zhang J, Hsu CE, Holmes JH: Understanding Behavioral Intent to Participate in Shared Decision-making in Medically Uncertain Situations. Methods of Information in Medicine 51:301–308, 2012.

Bennett I, Cohen D, Holmes JH, Holmes-Rovner M: Participatory design of a patient decision aid for treatment choice for perinatal depression. North American Primary Care Research Group 2014 Annual Meeting, New York, November 2014.

Mao JJ, Chung A, Benton A, Hill S, Ungar L, Leonard C, Hennessy S, Holmes JH. Online discussion of drug side effects and discontinuation among breast cancer survivors. Pharmacoepidemiology and Drug Safety 22(3):256-62, 2013.

Prabhu V, Lee T, Loeb S, Holmes JH, Gold H, Lepor HT, Penson D, Makarov D: Twitter response to the United States Preventive Services Task Force Recommendations against Screening with Prostate Specific Antigen. British Journal of Urology, accepted for publication March 2014.